Bibliotecas PUC-SP - Busca Integrada

Further studies of the role of Ser-16 in the regulation of the activity of phenylalanine hydroxylase.

Por Kowlessur, D, Yang, X J, Kaufman, S
Publicado em 1995

Characterization of the wild-type form of 4a-carbinolamine dehydratase and two naturally occurring mutants associated with hyperphenylalaninemia.

Por Johnen, G, Kowlessur, D, Citron, B A, Kaufman, S
Publicado em 1995

Catalytic-site characteristics of the porcine calpain II 80 kDa/18 kDa heterodimer revealed by selective reaction of its essential thiol group with two-hydronic-state time-dependen...

Por Mellor, G W, Sreedharan, S K, Kowlessur, D, Thomas, E W, Brocklehurst, K
Publicado em 1993

A re-appraisal of the structural basis of stereochemical recognition in papain. Insensitivity of binding-site-catalytic-site signalling to P2-chirality in a time-dependent inhibiti...

Por Templeton, W, Kowlessur, D, Thomas, E W, Topham, C M, Brocklehurst, K
Publicado em 1990

Dependence of the P2-S2 stereochemical selectivity of papain on the nature of the catalytic-site chemistry. Quantification of selectivity in the catalysed hydrolysis of the enantio...

Por Kowlessur, D, Thomas, E W, Topham, C M, Templeton, W, Brocklehurst, K
Publicado em 1990

Differences in the chemical and catalytic characteristics of two crystallographically 'identical' enzyme catalytic sites. Characterization of actinidin and papain by a combination...

Por Salih, E, Malthouse, J P, Kowlessur, D, Jarvis, M, O'Driscoll, M, Brocklehurst, K
Publicado em 1987

Identification of signalling and non-signalling binding contributions to enzyme reactivity. Alternative combinations of binding interactions provide for change in transition-state...

Por Kowlessur, D, Topham, C M, Thomas, E W, O'Driscoll, M, Templeton, W, Brocklehurst, K
Publicado em 1989

The interplay of electrostatic fields and binding interactions determining catalytic-site reactivity in actinidin. A possible origin of differences in the behaviour of actinidin an...

Por Kowlessur, D, O'Driscoll, M, Topham, C M, Templeton, W, Thomas, E W, Brocklehurst, K
Publicado em 1989

Structure of chymopapain M the late-eluted chymopapain deduced by comparative modelling techniques and active-centre characteristics determined by pH-dependent kinetics of catalysi...

Por Thomas, M P, Topham, C M, Kowlessur, D, Mellor, G W, Thomas, E W, Whitford, D, Brocklehurst, K
Publicado em 1994

Substrate-derived two-protonic-state electrophiles as sensitive kinetic specificity probes for cysteine proteinases. Activation of 2-pyridyl disulphides by hydrogen-bonding.

Por Brocklehurst, K, Kowlessur, D, O'Driscoll, M, Patel, G, Quenby, S, Salih, E, Templeton, W, Thomas, E W, Willenbrock, F
Publicado em 1987

The interplay of electrostatic and binding interactions determining active centre chemistry and catalytic activity in actinidin and papain.

Por Brocklehurst, K, O'Driscoll, M, Kowlessur, D, Phillips, I R, Templeton, W, Thomas, E W, Topham, C M, Wharton, C W
Publicado em 1989

Consequences of molecular recognition in the S1-S2 intersubsite region of papain for catalytic-site chemistry. Change in pH-dependence characteristics and generation of an inverse...

Por Brocklehurst, K, Kowlessur, D, Patel, G, Templeton, W, Quigley, K, Thomas, E W, Wharton, C W, Willenbrock, F, Szawelski, R J
Publicado em 1988

Supracrystallographic resolution of interactions contributing to enzyme catalysis by use of natural structural variants and reactivity-probe kinetics.

Por Brocklehurst, K, Brocklehurst, S M, Kowlessur, D, O'Driscoll, M, Patel, G, Salih, E, Templeton, W, Thomas, E, Topham, C M, Willenbrock, F
Publicado em 1988

Structure-function relationships in the cysteine proteinases actinidin, papain and papaya proteinase omega. Three-dimensional structure of papaya proteinase omega deduced by knowle...

Por Topham, C M, Salih, E, Frazao, C, Kowlessur, D, Overington, J P, Thomas, M, Brocklehurst, S M, Patel, M, Thomas, E W, Brocklehurst, K
Publicado em 1991

Distance determination in proteins using designed metal ion binding sites and site-directed spin labeling: application to the lactose permease of Escherichia coli.

Por Voss, J, Hubbell, W L, Kaback, H R, Pontieri, F E, Tanda, G, Di Chiara, G, Jemiolo, D K, Pagel, F T, Murgola, E J, Kraus, W L, McInerney, E M, Katzenellenbogen, B S, Nakamura, S, Shimooku, K, Akisue, T, Jinnai, H, Hitomi, T, Kiyohara, Y, Ogino, C, Yoshida, K, Nishizuka, Y, Furuya, K, Schegg, K M, Wang, H, King, D S, Schooley, D A, Driscoll, W J, Komatsu, K, Strott, C A, Hess, S, Chachisvilis, M, Timpmann, K, Jones, M R, Fowler, G J, Hunter, C N, Sundström, V, Park, I, Chung, J, Walsh, C T, Yun, Y, Strominger, J L, Shin, J, Sharma, H W, Sokoloski, J A, Perez, J R, Maltese, J Y, Sartorelli, A C, Stein, C A, Nichols, G, Khaled, Z, Telang, N T, Narayanan, R, Greenberg, D, Miao, C H, Ho, W T, Chung, D W, Davie, E W, Kalcheva, I D, Matsuda, Y, Plass, C, Chapman, V M, Li, X, Chang, Y H, Roner, M R, Lin, P N, Nepluev, I, Kong, L J, Joklik, W K, Buth, D G, Gordon, M S, Plaut, I, Drill, S L, Adams, L G, Polk, T A, Farah, M J, Winchester, R, Chen, Y, Rose, S, Selby, J, Borkowsky, W, Minnerath, J M, Wakem, L P, Comfort, L L, Sherman, F, Jemmerson, R, Johnen, G, Kowlessur, D, Citron, B A, Kaufman, S, Szalay, G, Ladel, C H, Kaufmann, S H, Moens, U, Seternes, O M, Hey, A W, Silsand, Y, Traavik, T, Johansen, B, Rekvig, O P, Tsui, L V, Guidotti, L G, Ishikawa, T, Chisari, F V, Shimizu, K D, Rebek, J, Feng, S, Kasahara, C, Rickles, R J, Schreiber, S L, Wang, X S, Yoder, M C, Zhou, S Z, Srivastava, A, George, J B, Li, S, Garrard, W T, Zheng, X, Saunders, T L, Camper, S A, Samuelson, L C, Ginsburg, D, Klishin, A, Tsintsadze, T, Lozovaya, N, Krishtal, O, Wang, W W, Shahrestanifar, M, Jin, J, Howells, R D, Kleppisch, T, Nelson, M T, Leonardsson, G, Peng, X R, Liu, K, Nordström, L, Carmeliet, P, Mulligan, R, Collen, D, Ny, T, Lee, K, Haugen, H S, Clegg, C H, Braun, R E, Hoovers, J M, Kalikin, L M, Johnson, L A, Alders, M, Redeker, B, Law, D J, Bliek, J, Steenman, M, Benedict, M, Wiegant, J, Simonet, W S, DeRose, M L, Bucay, N, Nguyen, H Q, Wert, S E, Zhou, L, Ulich, T R, Thomason, A, Danilenko, D M, Whitsett, J A, Marcos, J F, Beachy, R N, Houghten, R A, Blondelle, S E, Pérez-Payá, E, Squire, L R, Knowlton, B J, Muzi-Falconi, M, Kelly, T J, Liu, W, Wang, J, Sauter, N K, Pearce, D, Tam, J P, Lu, Y A, Liu, C F, Shao, J, Steber, C M, Esposito, R E, Long, M, Rosenberg, C, Gilbert, W, Woollett, L A, Osono, Y, Herz, J, Dietschy, J M, Du, L, Lykkesfeldt, J, Olsen, C E, Halkier, B A, Pan, T, Loria, A, Zhong, K, Pillet, N, Bonny, C, Schorderet, D F, Migliazza, A, Martinotti, S, Chen, W, Fusco, C, Ye, B H, Knowles, D M, Offit, K, Chaganti, R S, Dalla-Favera, R, Good, D W, George, T, Watts, B A, Rakic, P, Ramakrishnan, V
Publicado em 1995

The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4...

Por Wang, J H, Pepinsky, R B, Stehle, T, Liu, J H, Karpusas, M, Browning, B, Osborn, L, Russell, D W, Alexander, I E, Miller, A D, Sun, J, Thurin, J, Cooper, H S, Wang, P, Mackiewicz, M, Steplewski, Z, Blaszczyk-Thurin, M, Bayle, J H, Elenbaas, B, Levine, A J, Link, W, Konietzko, U, Kauselmann, G, Krug, M, Schwanke, B, Frey, U, Kuhl, D, van de Goor, J, Ramaswami, M, Kelly, R, Weng, Q P, Andrabi, K, Klippel, A, Kozlowski, M T, Williams, L T, Avruch, J, Donald, R G, Roos, D S, Chu, S, Noonan, B, Cavaignac, S, Trust, T J, Manne, J, Argeson, A C, Siracusa, L D, Strittmatter, W J, Roses, A D, Klebig, M L, Wilkinson, J E, Geisler, J G, Woychik, R P, Zemel, M B, Kim, J H, Woychik, R P, Michaud, E J, Kadwell, S H, Patel, I R, Wilkison, W O, Burns, C M, Richardson, J P, Kowlessur, D, Yang, X J, Kaufman, S, Linse, S, Jönsson, B, Chazin, W J, Schreiber, V, Hunting, D, Trucco, C, Gowans, B, Grunwald, D, De Murcia, G, De Murcia, J M, Wardell, B B, Michael, S D, Tung, K S, Todd, J A, Blankenhorn, E P, McEntee, K, Sudweeks, J D, Hansen, W K, Meeker, N D, Griffith, J S, Ma, A, Pena, J C, Chang, B, Margosian, E, Davidson, L, Alt, F W, Thompson, C B, Caplan, S, Zeliger, S, Wang, L, Baniyash, M, Fagerberg, J, Steinitz, M, Wigzell, H, Askelöf, P, Mellstedt, H, Sugawara, T, Holt, J A, Driscoll, D, Strauss, J F, Lin, D, Miller, W L, Patterson, D, Clancy, K P, Hart, I M, Clark, B J, Ramírez, A, Vidal, M, Bravo, A, Larcher, F, Jorcano, J L, Andersson, L I, Müller, R, Vlatakis, G, Mosbach, K, Huang, T S, Duyster, J, Wang, J Y, Durrant, J R, Klug, D R, Kwa, S L, van Grondelle, R, Porter, G, Dekker, J P, Friederich, M W, Gast, F U, Vacano, E, Hagerman, P J, Condorelli, G L, Testa, U, Valtieri, M, Vitelli, L, De Luca, A, Barberi, T, Montesoro, E, Campisi, S, Giordano, A, Peschle, C, Leung, D W, Peterson, P K, Weeks, R, Gekker, G, Chao, C C, Kaplan, A H, Balantac, N, Tompkins, C, Underiner, G E, Bursten, S, Prowse, K R, Greider, C W, Germann, T, Szeliga, J, Hess, H, Störkel, S, Podlaski, F J, Gately, M K, Schmitt, E, Rüde, E, Golovkina, T V, Dudley, J P, Jaffe, A B, Ross, S R, Morris, A, Morton, N E, Collins, A, Macpherson, J, Nelson, D, Sherman, S, Albini, A, Barillari, G, Benelli, R, Gallo, R C, Ensoli, B, Rubin, H, Yao, A, Chow, M, Downing, J F, Pasula, R, Wright, J R, Twigg, H L, Martin, W J, Zhang, X, Jefferson, A B, Auethavekiat, V, Majerus, P W, Pereira, R F, Halford, K W, O'Hara, M D, Leeper, D B, Sokolov, B P, Pollard, M D, Bagasra, O, Prockop, D J, Hirota, H, Yoshida, K, Kishimoto, T, Taga, T, Yahi, N, Fantini, J, Baghdiguian, S, Mabrouk, K, Tamalet, C, Rochat, H, Van Rietschoten, J, Sabatier, J M, Izdebski, J, Pinski, J, Horvath, J E, Halmos, G, Groot, K, Schally, A V, Hackstadt, T, Scidmore, M A, Rockey, D D, Wood, M W, VanDongen, H M, VanDongen, A M, Villalba, J M, Navarro, F, Córdoba, F, Serrano, A, Arroyo, A, Crane, F L, Navas, P, Quadt, R, Ishikawa, M, Janda, M, Ahlquist, P, Patil, S, Takezawa, D, Poovaiah, B W, Tang, H, Severinov, K, Goldfarb, A, Ebright, R H, Singh, K K, Samson, L, Bornemann, K D, Brewer, J W, Beck-Engeser, G B, Corley, R B, Haas, I G, Jäck, H M, Golub, T R, Barker, G F, Bohlander, S K, Hiebert, S W, Ward, D C, Bray-Ward, P, Morgan, E, Raimondi, S C, Rowley, J D, Gilliland, D G
Publicado em 1995