Bibliotecas PUC-SP - Busca Integrada

Editorial: Current approaches in infectious disease drug discovery

Por Floriano P. Silva-Jr, Siva S. Panda, Carolina Horta Andrade, Nicholas Furnham
Publicado no Frontiers in Chemistry (2022-11-01)

A computational method for predicting the most likely evolutionary trajectories in the stepwise accumulation of resistance mutations

Por Ruth Charlotte Eccleston, Emilia Manko, Susana Campino, Taane G Clark, Nicholas Furnham
Publicado no eLife (2023-12-01)

Structural and Genomic Insights Into Pyrazinamide Resistance in Mycobacterium tuberculosis Underlie Differences Between Ancient and Modern Lineages

Por Tanushree Tunstall, Jody Phelan, Charlotte Eccleston, Taane G. Clark, Taane G. Clark, Nicholas Furnham
Publicado no Frontiers in Molecular Biosciences (2021-07-01)

Combining structure and genomics to understand antimicrobial resistance

Por Tanushree Tunstall, Stephanie Portelli, Jody Phelan, Taane G. Clark, David B. Ascher, Nicholas Furnham
Publicado no Computational and Structural Biotechnology Journal (2020-01-01)

Exploring the evolution of novel enzyme functions within structurally defined protein superfamilies.

Por Nicholas Furnham, Ian Sillitoe, Gemma L Holliday, Alison L Cuff, Roman A Laskowski, Christine A Orengo, Janet M Thornton
Publicado no PLoS Computational Biology (2012-01-01)

Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity.

Por Nidhi Tyagi, Edward J Farnell, Colin M Fitzsimmons, Stephanie Ryan, Edridah Tukahebwa, Rick M Maizels, David W Dunne, Janet M Thornton, Nicholas Furnham
Publicado no PLoS Computational Biology (2015-10-01)

Unveiling the Kinomes of Leishmania infantum and L. braziliensis Empowers the Discovery of New Kinase Targets and Antileishmanial Compounds

Por Joyce V.B. Borba, Arthur C. Silva, Pablo I.P. Ramos, Nathalia Grazzia, Danilo C. Miguel, Eugene N. Muratov, Nicholas Furnham, Carolina H. Andrade
Publicado no Computational and Structural Biotechnology Journal (2019-01-01)

Tools and challenges in the use of routine clinical data for antimicrobial resistance surveillance

Por Kathryn E. Holt, Megan E. Carey, Clare Chandler, James H. Cross, Zoe A. Dyson, Nicholas Furnham, Rebecca E. Glover, Mollie Virgo, Gwenan M. Knight
Publicado no npj Antimicrobials and Resistance (2025-05-01)

Computationally-guided drug repurposing enables the discovery of kinase targets and inhibitors as new schistosomicidal agents.

Por Sandra Giuliani, Arthur C Silva, Joyce V V B Borba, Pablo I P Ramos, Ross A Paveley, Eugene N Muratov, Carolina Horta Andrade, Nicholas Furnham
Publicado no PLoS Computational Biology (2018-10-01)

Novel computational models offer alternatives to animal testing for assessing eye irritation and corrosion potential of chemicals

Por Arthur C. Silva, Joyce V.V.B. Borba, Vinicius M. Alves, Steven U.S. Hall, Nicholas Furnham, Nicole Kleinstreuer, Eugene Muratov, Alexander Tropsha, Carolina Horta Andrade
Publicado no Artificial Intelligence in the Life Sciences (2021-12-01)

In silico Strategies to Support Fragment-to-Lead Optimization in Drug Discovery

Por Lauro Ribeiro de Souza Neto, José Teófilo Moreira-Filho, Bruno Junior Neves, Bruno Junior Neves, Rocío Lucía Beatriz Riveros Maidana, Rocío Lucía Beatriz Riveros Maidana, Ana Carolina Ramos Guimarães, Nicholas Furnham, Carolina Horta Andrade, Floriano Paes Silva
Publicado no Frontiers in Chemistry (2020-02-01)

Fragment library screening by X-ray crystallography and binding site analysis on thioredoxin glutathione reductase of Schistosoma mansoni

Por Lauro Ribeiro de Souza Neto, Bogar Omar Montoya, José Brandão-Neto, Anil Verma, Sebastian Bowyer, José Teófilo Moreira-Filho, Rafael Ferreira Dantas, Bruno Junior Neves, Carolina Horta Andrade, Frank von Delft, Raymond J. Owens, Nicholas Furnham, Floriano Paes Silva-Jr
Publicado no Scientific Reports (2024-01-01)

Schistosomiasis Drug Discovery in the Era of Automation and Artificial Intelligence

Por José T. Moreira-Filho, Arthur C. Silva, Rafael F. Dantas, Barbara F. Gomes, Lauro R. Souza Neto, Jose Brandao-Neto, Jose Brandao-Neto, Raymond J. Owens, Raymond J. Owens, Nicholas Furnham, Bruno J. Neves, Floriano P. Silva-Junior, Carolina H. Andrade
Publicado no Frontiers in Immunology (2021-05-01)