Bibliotecas PUC-SP - Busca Integrada

Improved genome editing in human cell lines using the CRISPR method.

Por Ivan M Munoz, Piotr Szyniarowski, Rachel Toth, John Rouse, Christophe Lachaud
Publicado no PLoS ONE (2014-01-01)

Evolution of signal multiplexing by 14-3-3-binding 2R-ohnologue protein families in the vertebrates

Por Michele Tinti, Catherine Johnson, Rachel Toth, David E. K. Ferrier, Carol MacKintosh
Publicado no Open Biology (2012-01-01)

A chemical-genetic system to rapidly inhibit the PP2A-B56 phosphatase reveals a role at metaphase kinetochores

Por Lindsey A. Allan, Andrea Corno, Juan Manuel Valverde, Rachel Toth, Tony Ly, Adrian T. Saurin
Publicado no Nature Communications (2025-03-01)

Localization-Dependent and -Independent Roles of SLX4 in Regulating Telomeres

Por Jamie S.J. Wilson, Agueda M. Tejera, Dennis Castor, Rachel Toth, Maria A. Blasco, John Rouse
Publicado no Cell Reports (2013-09-01)

PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability

Por Vikram Tejwani, Thomas Carroll, Thomas Macartney, Susanne Bandau, Constance Alabert, Giulia Saredi, Rachel Toth, John Rouse
Publicado no Scientific Reports (2024-09-01)

Erk5 Is a Key Regulator of Naive-Primed Transition and Embryonic Stem Cell Identity

Por Charles A.C. Williams, Rosalia Fernandez-Alonso, Jinhua Wang, Rachel Toth, Nathanael S. Gray, Greg M. Findlay
Publicado no Cell Reports (2016-08-01)

A fluorescence lifetime-based FLIM-timer for measuring the protein turnover of transcription factor Nrf2 in live cells

Por Dina Dikovskaya, Claudia Bento-Pereira, Kanade Shiga, Andrea Corno, Maureen Higgins, Rachel Toth, Adrian T. Saurin, Albena T. Dinkova-Kostova
Publicado no Scientific Reports (2025-08-01)

Identification of the amino acids 300-600 of IRS-2 as 14-3-3 binding region with the importance of IGF-1/insulin-regulated phosphorylation of Ser-573.

Por Sabine S Neukamm, Rachel Toth, Nick Morrice, David G Campbell, Carol Mackintosh, Rainer Lehmann, Hans-Ulrich Haering, Erwin D Schleicher, Cora Weigert
Publicado no PLoS ONE (2012-01-01)

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

Por Gerta Hoxhaj, Edward Caddye, Ayaz Najafov, Vanessa P Houde, Catherine Johnson, Kumara Dissanayake, Rachel Toth, David G Campbell, Alan R Prescott, Carol MacKintosh
Publicado no eLife (2016-04-01)

A novel RLIM/RNF12 variant disrupts protein stability and function to cause severe Tonne–Kalscheuer syndrome

Por Francisco Bustos, Carmen Espejo-Serrano, Anna Segarra-Fas, Rachel Toth, Alison J. Eaton, Kristin D. Kernohan, Meredith J. Wilson, Lisa G. Riley, Greg M. Findlay
Publicado no Scientific Reports (2021-05-01)

RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation

Por Francisco Bustos, Anna Segarra-Fas, Viduth K. Chaugule, Lennart Brandenburg, Emma Branigan, Rachel Toth, Thomas Macartney, Axel Knebel, Ronald T. Hay, Helen Walden, Greg M. Findlay
Publicado no Cell Reports (2018-05-01)

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

Por Jacob Lauwring Andersen, Borbala Gesser, Erik Daa Funder, Christine Juul Fælled Nielsen, Helle Gotfred-Rasmussen, Mads Kirchheiner Rasmussen, Rachel Toth, Kurt Vesterager Gothelf, J. Simon C. Arthur, Lars Iversen, Poul Nissen
Publicado no Nature Communications (2018-10-01)

Generation of a chemical genetic model for JAK3

Por Judit Remenyi, Rangeetha Jayaprakash Naik, Jinhua Wang, Momchil Razsolkov, Alyssa Verano, Quan Cai, Li Tan, Rachel Toth, Samantha Raggett, Carla Baillie, Ryan Traynor, C. James Hastie, Nathanael S. Gray, J. Simon C. Arthur
Publicado no Scientific Reports (2021-05-01)

Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies.

Por Lee A Armstrong, Sven M Lange, Virginia Dee Cesare, Stephen P Matthews, Raja Sekhar Nirujogi, Isobel Cole, Anthony Hope, Fraser Cunningham, Rachel Toth, Rukmini Mukherjee, Denisa Bojkova, Franz Gruber, David Gray, Paul G Wyatt, Jindrich Cinatl, Ivan Dikic, Paul Davies, Yogesh Kulathu
Publicado no PLoS ONE (2021-01-01)

A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research.

Por Suzannah J Rihn, Andres Merits, Siddharth Bakshi, Matthew L Turnbull, Arthur Wickenhagen, Akira J T Alexander, Carla Baillie, Benjamin Brennan, Fiona Brown, Kirstyn Brunker, Steven R Bryden, Kerry A Burness, Stephen Carmichael, Sarah J Cole, Vanessa M Cowton, Paul Davies, Chris Davis, Giuditta De Lorenzo, Claire L Donald, Mark Dorward, James I Dunlop, Matthew Elliott, Mazigh Fares, Ana da Silva Filipe, Joseph R Freitas, Wilhelm Furnon, Rommel J Gestuveo, Anna Geyer, Daniel Giesel, Daniel M Goldfarb, Nicola Goodman, Rory Gunson, C James Hastie, Vanessa Herder, Joseph Hughes, Clare Johnson, Natasha Johnson, Alain Kohl, Karen Kerr, Hannah Leech, Laura Sandra Lello, Kathy Li, Gauthier Lieber, Xiang Liu, Rajendra Lingala, Colin Loney, Daniel Mair, Marion J McElwee, Steven McFarlane, Jenna Nichols, Kyriaki Nomikou, Anne Orr, Richard J Orton, Massimo Palmarini, Yasmin A Parr, Rute Maria Pinto, Samantha Raggett, Elaine Reid, David L Robertson, Jamie Royle, Natalia Cameron-Ruiz, James G Shepherd, Katherine Smollett, Douglas G Stewart, Meredith Stewart, Elena Sugrue, Agnieszka M Szemiel, Aislynn Taggart, Emma C Thomson, Lily Tong, Leah S Torrie, Rachel Toth, Margus Varjak, Sainan Wang, Stuart G Wilkinson, Paul G Wyatt, Eva Zusinaite, Dario R Alessi, Arvind H Patel, Ali Zaid, Sam J Wilson, Suresh Mahalingam
Publicado no PLoS Biology (2021-02-01)