Bibliotecas PUC-SP - Busca Integrada

Loss-of-function mutations in the dystonia gene THAP1 impair proteasome function by inhibiting PSMB5 expression

von Dylan E. Ramage, Drew W. Grant, Richard T. Timms
Veröffentlicht in Nature Communications (2025-02-01)

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex

von Richard T. Timms, Iva A. Tchasovnikarova, Robin Antrobus, Gordon Dougan, Paul J. Lehner
Veröffentlicht in Cell Reports (2016-10-01)

Fluorescence-based phenotypic selection allows forward genetic screens in haploid human cells.

von Lidia M Duncan, Richard T Timms, Eszter Zavodszky, Florencia Cano, Gordon Dougan, Felix Randow, Paul J Lehner
Veröffentlicht in PLoS ONE (2012-01-01)

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms

von Christopher H. Douse, Stuart Bloor, Yangci Liu, Maria Shamin, Iva A. Tchasovnikarova, Richard T. Timms, Paul J. Lehner, Yorgo Modis
Veröffentlicht in Nature Communications (2018-02-01)

The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1

von Sam A Menzies, Norbert Volkmar, Dick JH van den Boomen, Richard T Timms, Anna S Dickson, James A Nathan, Paul J Lehner
Veröffentlicht in eLife (2018-12-01)

Haploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases.

von Richard T Timms, Lidia M Duncan, Iva A Tchasovnikarova, Robin Antrobus, Duncan L Smith, Gordon Dougan, Michael P Weekes, Paul J Lehner
Veröffentlicht in PLoS Pathogens (2013-01-01)

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens

von Richard T. Timms, Sam A. Menzies, Iva A. Tchasovnikarova, Lea C. Christensen, James C. Williamson, Robin Antrobus, Gordon Dougan, Lars Ellgaard, Paul J. Lehner
Veröffentlicht in Nature Communications (2016-06-01)

Mechanism of Ψ-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase

von Xinyan Chen, Anat Raiff, Shanshan Li, Qiong Guo, Jiahai Zhang, Hualin Zhou, Richard T. Timms, Xuebiao Yao, Stephen J. Elledge, Itay Koren, Kaiming Zhang, Chao Xu
Veröffentlicht in Nature Communications (2024-04-01)

TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

von Christopher H. Douse, Iva A. Tchasovnikarova, Richard T. Timms, Anna V. Protasio, Marta Seczynska, Daniil M. Prigozhin, Anna Albecka, Jane Wagstaff, James C. Williamson, Stefan M. V. Freund, Paul J. Lehner, Yorgo Modis
Veröffentlicht in Nature Communications (2020-10-01)