The Transcription Factor T-Bet Is Regulated by MicroRNA-155 in Murine Anti-Viral CD8+ T Cells via SHIP-1

We report here that the expression of the transcription factor T-bet, which is known to be required for effector cytotoxic CD8+ T lymphocytes (CTL) generation and effector memory cell formation, is regulated in CTL by microRNA-155 (miR-155). Importantly, we show that the proliferative effect of miR-...

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Udgivet i:Frontiers in Immunology
Main Authors: Jennifer L. Hope, Christopher J. Stairiker, Panagiota I. Spantidea, Donald T. Gracias, Alison J. Carey, Adam J. Fike, Marjan van Meurs, Inge Brouwers-Haspels, Laurine C. Rijsbergen, Joseph A. Fraietta, Yvonne M. Mueller, Rosemarieke C. Klop, Erietta Stelekati, E. John Wherry, Stefan J. Erkeland, Peter D. Katsikis
Format: Artigo
Udgivet: Frontiers Media S.A. 2017-12-01
Fag:
MicroRNAs
CD8+ T cells
T-bet
Influenza
Src homology 2-containing inositol phosphatase-1
MiR-155
Online adgang:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01696/full
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http://journal.frontiersin.org/article/10.3389/fimmu.2017.01696/full

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