Anti-idiotype isolation of a broad and potent influenza A virus-neutralizing human antibody

The VH6-1 class of antibodies includes some of the broadest and most potent antibodies that neutralize influenza A virus. Here, we elicit and isolate anti-idiotype antibodies against germline versions of VH6-1 antibodies, use these to sort human leukocytes, and isolate a new VH6-1-class member, anti...

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Publicat a:Frontiers in Immunology
Autors principals: Adam S. Olia, Madhu Prabhakaran, Darcy R. Harris, Crystal Sao-Fong Cheung, Rebecca A. Gillespie, Jason Gorman, Abigayle Hoover, Nicholas C. Morano, Amine Ourahmane, Abhinaya Srikanth, Shuishu Wang, Weiwei Wu, Tongqing Zhou, Sarah F. Andrews, Masaru Kanekiyo, Lawrence Shapiro, Adrian B. McDermott, Peter D. Kwong
Format: Article
Publicat: Frontiers Media S.A. 2024-05-01
Matèries:
Anti-idiotype
Broadly neutralizing antibody
Cryo-EM
Influenza A virus
MEDI8852
VH6-1 class
Accés en línia:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1399960/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1399960/full

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