Pancreatic Cancer Signaling Pathways, Genetic Alterations, and Tumor Microenvironment: The Barriers Affecting the Method of Treatment

Genetic alterations, especially the K-Ras mutation, carry the heaviest burden in the progression of pancreatic precursor lesions into pancreatic ductal adenocarcinoma (PDAC). The tumor microenvironment is one of the challenges that hinder the therapeutic approaches from functioning sufficiently and...

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Pubblicato in:Biomedicines
Autori principali: Darya Javadrashid, Amir Baghbanzadeh, Afshin Derakhshani, Patrizia Leone, Nicola Silvestris, Vito Racanelli, Antonio Giovanni Solimando, Behzad Baradaran
Natura: Articolo
Pubblicazione: MDPI AG 2021-04-01
Soggetti:
Pancreatic cancer
Pancreatic adenocarcinoma
PDAC
Immune checkpoint
Signaling pathway
Gene mutation
Accesso online:https://www.mdpi.com/2227-9059/9/4/373
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https://www.mdpi.com/2227-9059/9/4/373

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