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The antiviral drug tenofovir, an inhibitor of Pannexin-1-mediated ATP release, prevents liver and skin fibrosis by downregulating adenosine levels in the liver and skin.
Fibrosing diseases are a leading cause of morbidity and mortality worldwide and, therefore, there is a need for safe and effective antifibrotic therapies. Adenosine, generated extracellularly by the dephosphorylation of adenine nucleotides, ligates specific receptors which play a critical role in de...
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| Publicat a: | PLoS ONE |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Article |
| Publicat: |
Public Library of Science (PLoS)
2017-01-01
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| Accés en línia: | http://europepmc.org/articles/PMC5690602?pdf=render |
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