Identification of the factor XII contact activation site enables sensitive coagulation diagnostics

Blood coagulation is started by contact to surfaces and this is the principle for a commonly used diagnostic clotting test, aPTT. Here, the authors identify the structure in coagulation factor XII that initiates surface-driven coagulation and use the information to develop improved aPTT assays.

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Publicado no:Nature Communications
Main Authors: Marco Heestermans, Clément Naudin, Reiner K. Mailer, Sandra Konrath, Kristin Klaetschke, Anne Jämsä, Maike Frye, Carsten Deppermann, Giordano Pula, Piotr Kuta, Manuel A. Friese, Mathias Gelderblom, Albert Sickmann, Roger J. S. Preston, Jerzy-Roch Nofer, Stefan Rose-John, Lynn M. Butler, Ophira Salomon, Evi X. Stavrou, Thomas Renné
Formato: Artigo
Publicado em: Nature Portfolio 2021-09-01
Acesso em linha:https://doi.org/10.1038/s41467-021-25888-7
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https://doi.org/10.1038/s41467-021-25888-7

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