Structural and Nonstructural Genes Contribute to the Genetic Diversity of RNA Viruses

ABSTRACT One paradigm to explain the complexity of viral RNA populations is that the low fidelity of the RNA-dependent RNA polymerase (RdRp) drives high mutation rates and consequently genetic diversity. Like most RNA viruses, wild-type yellow fever virus (YFV) replication is error-prone due to the...

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Publicado no:mBio
Main Authors: Natalie D. Collins, Andrew S. Beck, Steven G. Widen, Thomas G. Wood, Stephen Higgs, Alan D. T. Barrett
Formato: Artigo
Publicado em: American Society for Microbiology 2018-11-01
Assuntos:
RNA viruses
Attenuation
Diversity
Viral population
Vaccine
Yellow fever
Acesso em linha:https://journals.asm.org/doi/10.1128/mBio.01871-18
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https://journals.asm.org/doi/10.1128/mBio.01871-18

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