The impact of hypoxia on B cells in COVID-19

Summary: Background: Prominent early features of COVID-19 include severe, often clinically silent, hypoxia and a pronounced reduction in B cells, the latter important in defence against SARS-CoV-2. This presentation resembles the phenotype of mice with VHL-deficient B cells, in which Hypoxia-Induci...

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Pubblicato in:EBioMedicine
Autori principali: Prasanti Kotagiri, Federica Mescia, Aimee L. Hanson, Lorinda Turner, Laura Bergamaschi, Ana Peñalver, Nathan Richoz, Stephen D. Moore, Brian M. Ortmann, Benjamin J. Dunmore, Michael D. Morgan, Zewen Kelvin Tuong, Berthold Göttgens, Mark Toshner, Christoph Hess, Patrick. H. Maxwell, Menna. R. Clatworthy, James A. Nathan, John R. Bradley, Paul A. Lyons, Natalie Burrows, Kenneth G.C. Smith
Natura: Articolo
Pubblicazione: Elsevier 2022-03-01
Soggetti:
COVID-19
Hypoxia
B cells
Lymphopenia
Accesso online:http://www.sciencedirect.com/science/article/pii/S2352396422000627
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http://www.sciencedirect.com/science/article/pii/S2352396422000627

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