Intranasal H5N1 vaccines, adjuvanted with chitosan derivatives, protect ferrets against highly pathogenic influenza intranasal and intratracheal challenge.

We investigated the protective efficacy of two intranasal chitosan (CSN and TM-CSN) adjuvanted H5N1 Influenza vaccines against highly pathogenic avian Influenza (HPAI) intratracheal and intranasal challenge in a ferret model. Six groups of 6 ferrets were intranasally vaccinated twice, 21 days apart,...

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Argitaratua izan da:PLoS ONE
Egile Nagusiak: Alex J Mann, Nicolas Noulin, Andrew Catchpole, Koert J Stittelaar, Leon de Waal, Edwin J B Veldhuis Kroeze, Michael Hinchcliffe, Alan Smith, Emanuele Montomoli, Simona Piccirella, Albert D M E Osterhaus, Alastair Knight, John S Oxford, Giulia Lapini, Rebecca Cox, Rob Lambkin-Williams
Formatua: Artikulua
Argitaratua: Public Library of Science (PLoS) 2014-01-01
Sarrera elektronikoa:http://europepmc.org/articles/PMC4029577?pdf=render
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http://europepmc.org/articles/PMC4029577?pdf=render

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