The AMPylase FIC-1 modulates TGF-β signaling in Caenorhabditis elegans

Post-translational protein modifications are essential for the spatio-temporal regulation of protein function. In this study, we examine how the activity of the Caenorhabditis elegans AMPylase FIC-1 modulates physiological processes in vivo. We find that over-expression (OE) of the constitutive AMPy...

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Publicado en:Frontiers in Molecular Neuroscience
Main Authors: Mirella A. Hernandez-Lima, Margaret Champion, Zachary Mattiola, Matthias C. Truttmann
Formato: Artigo
Publicado: Frontiers Media S.A. 2022-11-01
Assuntos:
AMPylation/adenylylation
Chaperones
Proteostasis
Transforming growth factor
FIC activity
Acceso en liña:https://www.frontiersin.org/articles/10.3389/fnmol.2022.912734/full
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https://www.frontiersin.org/articles/10.3389/fnmol.2022.912734/full

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