Circulating FH Protects Kidneys From Tubular Injury During Systemic Hemolysis

Intravascular hemolysis of any cause can induce acute kidney injury (AKI). Hemolysis-derived product heme activates the innate immune complement system and contributes to renal damage. Therefore, we explored the role of the master complement regulator Factor H (FH) in the kidney's resistance to...

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Publicado no:Frontiers in Immunology
Principais autores: Nicolas S. Merle, Juliette Leon, Victoria Poillerat, Anne Grunenwald, Idris Boudhabhay, Samantha Knockaert, Tania Robe-Rybkine, Carine Torset, Matthew C. Pickering, Sophie Chauvet, Veronique Fremeaux-Bacchi, Lubka T. Roumenina
Formato: Artigo
Publicado em: Frontiers Media S.A. 2020-08-01
Assuntos:
Complement – immunological term
Complement factor H
Hemolysis
Kidney
Acute tubular damage
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2020.01772/full
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https://www.frontiersin.org/article/10.3389/fimmu.2020.01772/full

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