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Effect of HSV-IL12 Loaded Tumor Cell-Based Vaccination in a Mouse Model of High-Grade Neuroblastoma

We designed multimodal tumor vaccine that consists of irradiated tumor cells infected with the oncolytic IL-12-expressing HSV-1 virus, M002. This vaccine was tested against the syngeneic neuroblastoma mouse model Neuro 2a injected into the right caudate nucleus of the immunocompetent A/J mice. Mice...

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Detalhes bibliográficos
Publicado no:Journal of Immunology Research
Main Authors: David F. Bauer, Larisa Pereboeva, G. Yancey Gillespie, Gretchen A. Cloud, Osama Elzafarany, Catherine Langford, James M. Markert, Lawrence S. Lamb Jr.
Formato: Artigo
Publicado em: Wiley 2016-01-01
Acesso em linha:http://dx.doi.org/10.1155/2016/2568125
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