PEGylated Domain I of Beta-2-Glycoprotein I Inhibits the Binding, Coagulopathic, and Thrombogenic Properties of IgG From Patients With the Antiphospholipid Syndrome

APS is an autoimmune disease in which antiphospholipid antibodies (aPL) cause vascular thrombosis and pregnancy morbidity. In patients with APS, aPL exert pathogenic actions by binding serum beta-2-glycoprotein I (β2GPI) via its N-terminal domain I (DI). We previously showed that bacterially-express...

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Publicado no:Frontiers in Immunology
Main Authors: Thomas C. R. McDonnell, Rohan Willis, Charis Pericleous, Vera M. Ripoll, Ian P. Giles, David. A. Isenberg, Allan R. Brasier, Emilio B. Gonzalez, Elizabeth Papalardo, Zurina Romay-Penabad, Mohammad Jamaluddin, Yiannis Ioannou, Anisur Rahman
Formato: Artigo
Publicado em: Frontiers Media S.A. 2018-10-01
Assuntos:
Antiphospholipid syndrome
PEGylation
Domain I
Therapeutics
Biologics
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2018.02413/full
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https://www.frontiersin.org/article/10.3389/fimmu.2018.02413/full

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