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Scaffold dependent histone deacetylase (HDAC) inhibitor induced re-equilibration of the subcellular localization and post-translational modification state of class I HDACs.
The mechanism of action of histone deacetylase inhibitors (HDACi) is mainly attributed to the inhibition of the deacetylase catalytic activity for their histone substrates. In this study, we analyzed the abundance of class I HDACs in the cytosolic, nuclear soluble and chromatin bound cellular fracti...
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| Publicado no: | PLoS ONE |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Publicado em: |
Public Library of Science (PLoS)
2017-01-01
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| Acesso em linha: | http://europepmc.org/articles/PMC5646865?pdf=render |
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