Chiral Pyridine-3,5-bis- (L-phenylalaninyl-L-leucinyl) Schiff Base Peptides as Potential Anticancer Agents: Design, Synthesis, and Molecular Docking Studies Targeting Lactate Dehydrogenase-A

A series of branched tetrapeptide Schiff bases <b>3</b>&#8722;<b>6</b> were designed and synthesized from corresponding tetrapeptide hydrazide <b>2</b> as a starting material.In vitroevaluation of the synthesized compounds <b>4</b>&#8722;<b&...

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Опубликовано в: :Molecules
Главные авторы: Abd El-Galil E. Amr, Randa E. Abdel Mageid, Mohamed El-Naggar, Ahmed M. Naglah, Eman S. Nossier, Elsayed A. Elsayed
Формат: Статья
Опубликовано: MDPI AG 2020-02-01
Предметы:
Amino acids
Tetrapeptides
Schiff bases
Anticancer evaluation
P53 ubiquitination
Ldha
Molecular docking
Online-ссылка:https://www.mdpi.com/1420-3049/25/5/1096
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