Study protocol for controlled human infection for penicillin G against Streptococcus pyogenes: a double-blinded, placebo-controlled, randomised trial to determine the minimum concentration required to prevent experimental pharyngitis (the CHIPS trial)

Introduction Regular intramuscular benzathine penicillin G injections have been the cornerstone of rheumatic heart disease (RHD) secondary prophylaxis since the 1950s. As the pharmacological correlate of protection remains unknown, it is difficult to recommend changes to this established regimen. De...

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I publikationen:BMJ Open
Huvudupphovsmän: Kevin T Batty, Jonathan Carapetis, Thomas L Snelling, Julie A Marsh, Andrew C Steer, Laurens Manning, Joshua Osowicki, Sam Salman, James McCarthy, Joseph Kado, Thel Khin Hla, Renae Barr, Stephanie L Enkel
Materialtyp: Artikel
Publicerad: BMJ Publishing Group 2022-12-01
Länkar:https://bmjopen.bmj.com/content/12/12/e064022.full
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https://bmjopen.bmj.com/content/12/12/e064022.full

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