Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection

Abstract The generation of high-quality antibody responses to Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP), the primary surface antigen of Pf sporozoites, is paramount to the development of an effective malaria vaccine. Here we present an in-depth structural and functional analysis of...

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Detaylı Bibliyografya
Yayımlandı:Nature Communications
Asıl Yazarlar: Gregory M. Martin, Jonathan L. Torres, Tossapol Pholcharee, David Oyen, Yevel Flores-Garcia, Grace Gibson, Re’em Moskovitz, Nathan Beutler, Diana D. Jung, Jeffrey Copps, Wen-Hsin Lee, Gonzalo Gonzalez-Paez, Daniel Emerling, Randall S. MacGill, Emily Locke, C. Richter King, Fidel Zavala, Ian A. Wilson, Andrew B. Ward
Materyal Türü: Makale
Baskı/Yayın Bilgisi: Nature Portfolio 2023-07-01
Online Erişim:https://doi.org/10.1038/s41467-023-40151-x
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https://doi.org/10.1038/s41467-023-40151-x

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