Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4

Abstract Background Apolipoprotein E4 (APOE4) is associated with a greater response to neuroinflammation and the risk of developing late-onset Alzheimer’s disease (AD), but the mechanisms for this association are not clear. The activation of calcium-dependent cytosolic phospholipase A2 (cPLA2) is in...

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Publicado en:Molecular Neurodegeneration
Main Authors: Shaowei Wang, Boyang Li, Victoria Solomon, Alfred Fonteh, Stanley I. Rapoport, David A. Bennett, Zoe Arvanitakis, Helena C. Chui, Patrick M. Sullivan, Hussein N. Yassine
Formato: Artigo
Publicado: BMC 2022-06-01
Assuntos:
CPLA2
ApoE4
Alzheimer’s disease
P38 MAPK
Neuroinflammation
Oxidative stress
Acceso en liña:https://doi.org/10.1186/s13024-022-00549-5
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https://doi.org/10.1186/s13024-022-00549-5

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