SOCS3 Suppression Promoted the Recruitment of CD11b+Gr-1−F4/80−MHCII− Early-Stage Myeloid-Derived Suppressor Cells and Accelerated Interleukin-6-Related Tumor Invasion via Affecting Myeloid Differentiation in Breast Cancer

Interleukin-6 (IL-6) is an important trigger for the expansion and recruitment of myeloid-derived suppressor cells (MDSCs), which are regarded to be major coordinators of the immunosuppressive tumor microenvironment. In this study, we constructed IL-6-knockdown breast cancer mice models to explore t...

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Opis bibliograficzny
Wydane w:Frontiers in Immunology
Główni autorzy: Wenwen Zhang, Mengmeng Jiang, Jieying Chen, Rui Zhang, Yingnan Ye, Pengpeng Liu, Wenwen Yu, Jinpu Yu
Format: Artykuł
Wydane: Frontiers Media S.A. 2018-07-01
Hasła przedmiotowe:
Breast cancer
Interleukin-6
Early-stage myeloid-derived suppressor cells
SOCS3
The JAK/STAT signal pathway
Myeloid differentiation
Dostęp online:https://www.frontiersin.org/article/10.3389/fimmu.2018.01699/full
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https://www.frontiersin.org/article/10.3389/fimmu.2018.01699/full

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