LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes

BACKGROUND Preclinical studies suggest that cholesterol accumulation leads to insulin resistance. We previously reported that alterations in a monocyte cholesterol metabolism transcriptional network (CMTN) — suggestive of cellular cholesterol accumulation — were cross-sectionally associated with obe...

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Detalhes bibliográficos
Publicado no:The Journal of Clinical Investigation
Main Authors: Jingzhong Ding, Anh Tram Nguyen, Kurt Lohman, Michael T. Hensley, Daniel Parker, Li Hou, Jackson Taylor, Deepak Voora, Janet K. Sawyer, Elena Boudyguina, Michael P. Bancks, Alain Bertoni, James S. Pankow, Jerome I. Rotter, Mark O. Goodarzi, Russell P. Tracy, David M. Murdoch, Daniel Duprez, Stephen S. Rich, Bruce M. Psaty, David Siscovick, Christopher B. Newgard, David Herrington, Ina Hoeschele, Steven Shea, James H. Stein, Manesh Patel, Wendy Post, David Jacobs Jr., John S. Parks, Yongmei Liu
Formato: Artigo
Publicado em: American Society for Clinical Investigation 2024-07-01
Assuntos:
Metabolism
Acesso em linha:https://doi.org/10.1172/JCI173278
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https://doi.org/10.1172/JCI173278

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