Case report: Challenges in immune reconstitution following hematopoietic stem cell transplantation for CTLA-4 insufficiency-like primary immune regulatory disorders

Cytotoxic T-lymphocyte antigen-4 (CTLA-4) haploinsufficiency is a T-cell hyperactivation disorder that can manifest with both immunodeficiency and immune dysregulation. Approximately one-third of patients may present mild symptoms and remain stable under supportive care. The remaining patients may d...

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Publicado no:Frontiers in Immunology
Main Authors: Adriana Margarit-Soler, Àngela Deyà-Martínez, Juan Torres Canizales, Alexandru Vlagea, Ana García-García, Júlia Marsal, Maria Trabazo Del Castillo, Sílvia Planas, Sílvia Simó, Ana Esteve-Sole, María Suárez-Lledó Grande, Isabel Badell, Montserrat Rovira Tarrats, Francesc Fernández-Avilés, Laia Alsina
Formato: Artigo
Publicado em: Frontiers Media S.A. 2022-12-01
Assuntos:
CTLA-4
Primary immunodeficiency
Hematopoietic stem cell transplantation
Abatacept
Immune reconstitution
Chimerism
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1070068/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1070068/full

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