A Genome-Wide Association Study of 2304 Extreme Longevity Cases Identifies Novel Longevity Variants

We performed a genome-wide association study (GWAS) of human extreme longevity (EL), defined as surviving past the 99th survival percentile, by aggregating data from four centenarian studies. The combined data included 2304 EL cases and 5879 controls. The analysis identified a locus in CDKN2B-AS1 (r...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:International Journal of Molecular Sciences
Egile Nagusiak: Harold Bae, Anastasia Gurinovich, Tanya T. Karagiannis, Zeyuan Song, Anastasia Leshchyk, Mengze Li, Stacy L. Andersen, Konstantin Arbeev, Anatoliy Yashin, Joseph Zmuda, Ping An, Mary Feitosa, Cristina Giuliani, Claudio Franceschi, Paolo Garagnani, Jonas Mengel-From, Gil Atzmon, Nir Barzilai, Annibale Puca, Nicholas J. Schork, Thomas T. Perls, Paola Sebastiani
Formatua: Artikulua
Argitaratua: MDPI AG 2022-12-01
Gaiak:
Human longevity
Genetic variants
Protein signatures
Sarrera elektronikoa:https://www.mdpi.com/1422-0067/24/1/116
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