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The Biology of Autoimmune Response in the Scurfy Mice that Lack the CD4+Foxp3+ Regulatory T-Cells

Due to a mutation in the Foxp3 transcription factor, Scurfy mice lack regulatory T-cells that maintain self-tolerance of the immune system. They develop multi-organ inflammation (MOI) and die around four weeks old. The affected organs are skin, tail, lungs and liver. In humans, endocrine and gastroi...

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Publicado no:Biology
Main Authors: Shu Man Fu, John T. Kung, Felicia Gaskin, Rahul Sharma, Shyr-Te Ju
Formato: Artigo
Publicado em: MDPI AG 2012-04-01
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Acesso em linha:http://www.mdpi.com/2079-7737/1/1/18
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