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XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent.
We have reported that the radical scavenger XJB-5-131 attenuates or reverses progression of the disease phenotype in the HdhQ(150/150) mouse, a slow onset model of HD. Here, we tested whether XJB-5-131 has beneficial effects in R6/2 mice, a severe early onset model of HD. We found that XJB-5-131 has...
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| Publicado no: | PLoS ONE |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Publicado em: |
Public Library of Science (PLoS)
2018-01-01
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| Acesso em linha: | http://europepmc.org/articles/PMC5890981?pdf=render |
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