B4GALNT3 regulates glycosylation of sclerostin and bone massResearch in context

Summary: Background: Global sclerostin inhibition reduces fracture risk efficiently but has been associated with cardiovascular side effects. The strongest genetic signal for circulating sclerostin is in the B4GALNT3 gene region, but the causal gene is unknown. B4GALNT3 expresses the enzyme beta-1,...

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Enregistré dans:
Détails bibliographiques
Publié dans:EBioMedicine
Auteurs principaux: Sofia Movérare-Skrtic, Jakob Voelkl, Karin H. Nilsson, Maria Nethander, Trang Thi Doan Luong, Ioana Alesutan, Lei Li, Jianyao Wu, Karin Horkeby, Marie K. Lagerquist, Antti Koskela, Juha Tuukkanen, Jon H. Tobias, Ulf H. Lerner, Petra Henning, Claes Ohlsson
Format: Article
Publié: Elsevier 2023-05-01
Sujets:
Osteoporosis
Osteoblasts
Fracture risk
Mendelian randomization
Accès en ligne:http://www.sciencedirect.com/science/article/pii/S2352396423001111
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http://www.sciencedirect.com/science/article/pii/S2352396423001111

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