MicroRNA-4732-3p Is Dysregulated in Breast Cancer Patients with Cardiotoxicity, and Its Therapeutic Delivery Protects the Heart from Doxorubicin-Induced Oxidative Stress in Rats

Anthracycline-induced cardiotoxicity is the most severe collateral effect of chemotherapy originated by an excess of oxidative stress in cardiomyocytes that leads to cardiac dysfunction. We assessed clinical data from patients with breast cancer receiving anthracyclines and searched for discriminati...

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Detalhes bibliográficos
Publicado no:Antioxidants
Main Authors: Rafael Sánchez-Sánchez, Ignacio Reinal, Esteban Peiró-Molina, Marc Buigues, Sandra Tejedor, Amparo Hernándiz, Marta Selva, David Hervás, Antonio J. Cañada, Akaitz Dorronsoro, Ana Santaballa, Carmen Salvador, Florian Caiment, Jos Kleinjans, Luis Martínez-Dolz, Isabel Moscoso, Ricardo Lage, José R. González-Juanatey, Joaquín Panadero, Ernesto Aparicio-Puerta, Antonio Bernad, Pilar Sepúlveda
Formato: Artigo
Publicado em: MDPI AG 2022-09-01
Assuntos:
Cardiotoxicity
Doxorubicin
MiR-4732-3p
Oxidative stress
Fibrosis
Angiogenesis
Acesso em linha:https://www.mdpi.com/2076-3921/11/10/1955
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