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Construction of a fusion plasmid containing the PSCA gene and cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and its anti-tumor effect in an animal model of prostate cancer
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a negative regulator of T cell activation, which competes with CD28 for B7.1/B7.2 binding, and which has a greater affinity. Fusion of specific antigens to extracellular domain of CTLA4 represents a promising approach to increase the immunogeni...
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| Publicado no: | Brazilian Journal of Medical and Biological Research Brazilian Journal of Medical and Biological Research, Volume: 49, Issue: 11, Article number: e5620, Published: 24 OCT 2016 |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
Associação Brasileira de Divulgação Científica
2016
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| Assuntos: | |
| Acesso em linha: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001100601&lng=en&tlng=en |
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