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Anti-Pneumocystis Activities of Aromatic Diamidoxime Prodrugs

Aromatic dicationic compounds, such as pentamidine, have potent antimicrobial activities. Clinical use of these compounds has been restricted, however, by their toxicity and limited oral activity. A novel approach, using amidoxime derivatives as prodrugs, has recently been proposed to overcome these...

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Detalhes bibliográficos
Main Authors:	Hall, James Edwin, Kerrigan, John E., Ramachandran, Kishore, Bender, Brendan C., Stanko, Jason P., Jones, Susan K., Patrick, Donald A., Tidwell, Richard R., Byrne, William R., Welkos, Susan L., Pitt, M. Louise, Davis, Kelly J., Brueckner, Ralf P., Ezzell, John W., Nelson, Gene O., Vaccaro, Joseph R., Battersby, Luann C., Friedlander, Arthur M., Hawley, Shaun R., Bray, Patrick G., Mungthin, Mathirut, Atkinson, Jill D., O’Neill, Paul M., Ward, Stephen A., Cundy, Kenneth C., Sueoka, Cathy, Lynch, Geoffrey R., Griffin, Linda, Lee, William A., Shaw, Jeng-Pyng, Matsuo, Hirotami, Ryu, Miwako, Nagata, Aya, Uchida, Takahiro, Kawakami, Jun-Ichi, Yamamoto, Koujirou, Iga, Tatsuji, Sawada, Yasufumi, Trépanier, Eric F., Nafziger, Anne N., Amsden, Guy W., Izumikawa, Koichi, Hirakata, Yoichi, Yamaguchi, Toshiyuki, Yoshida, Ryoji, Tanaka, Hironori, Takemura, Hiromu, Maesaki, Shigefumi, Tomono, Kazunori, Kaku, Mitsuo, Izumikawa, Kin-Ichi, Kamihira, Shimeru, Kohno, Shigeru, Nagata, Kumiko, Hirai, Kei-Ichi, Koyama, Junko, Wada, Yasunao, Tamura, Toshihide, Bébéar, C. M., Renaudin, H., Boudjadja, A., Bébéar, C., Welton, L. A., Thal, L. A., Perri, M. B., Donabedian, S., McMahon, J., Chow, J. W., Zervos, M. J., Wang, Jian-Ying, Burger, Richard M., Drlica, Karl, Fattorini, Lanfranco, Xiao, Yan, Mattei, Maurizio, Li, Yongjun, Iona, Elisabetta, Ricci, Maria Luisa, Thoresen, Ove Fredrik, Creti, Roberta, Orefici, Graziella, Rogers, M. John, Cundliffe, Eric, McCutchan, Thomas F., Kobayashi, Nobumichi, Taniguchi, Koki, Urasawa, Shozo, Rybak, Michael J., Cappelletty, Diane M., Moldovan, Tabitha, Aeschlimann, Jeffrey R., Kaatz, Glenn W., von Recklinghausen, G., Schmid, E. N., Vollmer, A., Ansorg, R., Evans, Martin E., Titlow, William B., Zervos, M., Nelson, M., Boschman, Cynthia R., Bodnar, Ulana R., Tornatore, Michelle A., Obias, Arlene A., Noskin, Gary A., Englund, Kristin, Postelnick, Michael A., Suriano, Terra, Peterson, Lance R., van Langevelde, Petra, Kwappenberg, Kitty M. C., Groeneveld, Paul H. P., Mattie, Herman, van Dissel, Jaap T., den Hollander, Jan G., Mouton, Johan W., Verbrugh, Henri A., Fuursted, Kurt, Ogawa, Atsuko, Hashida-Okado, Takashi, Endo, Masahiro, Yoshioka, Hirofumi, Tsuruo, Takashi, Takesako, Kazutoh, Kato, Ikunoshin, Walker, Scott, Tailor, Sandra A. N., Lee, Mark, Louie, Lisa, Louie, Marie, Simor, Andrew E., Swenson, Christine E., Perkins, Walter R., Roberts, Patricia, Ahmad, Imran, Stevens, Rachel, Stevens, David A., Janoff, Andrew S., Rutman, Andrew, Dowling, Ruth, Wills, Peter, Feldman, Charles, Cole, Peter J., Wilson, Robert, Paterson, Jesse, Uriel, Clara, Egron, Marie-Jose, Herscovici, Jean, Antonakis, Kostas, Alaoui-Jamali, Moulay A., Yoshizumi, Satoshi, Domon, Haruki, Miyazaki, Shuichi, Yamaguchi, Keizo, Beutner, Karl R., Tyring, Stephen K., Trofatter, Kenneth F., Douglas, John M., Spruance, Spotswood, Owens, Mary L., Fox, Terry L., Hougham, Andrina J., Schmitt, Kathy A., Williams, Kerstin J., Chung, Gavin A. C., Piddock, Laura J. V., Bantia, Shanta, Ghate, Anita A., Ananth, Sandya L., Babu, Y. Sudhakar, Air, Gillian M., Walsh, Gerald M., Mirochnick, Mark, Capparelli, Edmund, Dankner, Wayne, Sperling, Rhoda S., van Dyke, Russ, Spector, Stephen A., Smith, Gillian M., Slocombe, Brian, Abbott, Karen H., Mizen, Linda W., Brasseur, Philippe, Lecoublet, Sophie, Kapel, Nathalie, Favennec, Loic, Ballet, Jean J., Adams, John M., Shelton, Mark J., Hewitt, Ross G., Grasela, Thaddeus H., DeRemer, Mary, Morse, Gene D., Gniadkowski, Marek, Schneider, Ines, Pałucha, Andrzej, Jungwirth, Renate, Mikiewicz, Barbara, Bauernfeind, Adolf, Liu, Shwu-Huey, Grove, Kristie L., Cheng, Yung-Chi, Nicolau, David P., Nie, Lin, Tessier, Pamela R., Kourea, Helen P., Nightingale, Charles H., Perkins, Margaret E., Wu, Teresa W., Le Blancq, Sylvie M., Tod, Michel, Lortholary, Olivier, Seytre, Delphine, Semaoun, Rémi, Uzzan, Bernard, Guillevin, Loïc, Casassus, Philippe, Petitjean, Olivier, Hoellman, Dianne B., Visalli, Melissa A., Jacobs, Michael R., Appelbaum, Peter C., Bédos, Jean-Pierre, Rieux, Véronique, Bauchet, Jacqueline, Muffat-Joly, Martine, Carbon, Claude, Azoulay-Dupuis, Esther, Christophers, Jacqueline, Clayton, Julie, Craske, John, Ward, Rosemary, Collins, Peter, Trowbridge, Martin, Darby, Graham, Verweij, Paul E., Oakley, Karen L., Morrissey, Jacqui, Morrissey, Graham, Denning, David W., Speldooren, Valérie, Heym, Beate, Labia, Roger, Nicolas-Chanoine, Marie-Hélène, Chien, Shu-Chean, Wong, Frank A., Fowler, Cynthia L., Callery-D’Amico, Susan V., Williams, R. Rex, Nayak, Ramchandra, Chow, Andrew T., Hammonds, Timothy R., Maxwell, Anthony, Jenkins, John R., Schwank, Silvia, Rajacic, Zarko, Zimmerli, Werner, Blaser, Jürg, Clemons, Karl V., De Wit, S., O’Doherty, E., Edwards, J., Yates, R., Smith, R. P., Clumeck, A. N.
Formato:	Artigo
Idioma:	English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English
Publicado em:	American Society for Microbiology 1998
Assuntos:	Experimental Therapeutics Mechanisms of Action: Physiological Effects Pharmacology Susceptibility Mechanisms of Resistance Letters to the Editor Clinical Therapeutics Antiviral Agents Analytical Procedures
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC105515/ https://ncbi.nlm.nih.gov/pubmed/9517949 https://ncbi.nlm.nih.gov/pmc/articles/PMC105516/ https://ncbi.nlm.nih.gov/pubmed/9517950 https://ncbi.nlm.nih.gov/pmc/articles/PMC105517/ https://ncbi.nlm.nih.gov/pubmed/9517951 https://ncbi.nlm.nih.gov/pmc/articles/PMC105518/ https://ncbi.nlm.nih.gov/pubmed/9517952 https://ncbi.nlm.nih.gov/pmc/articles/PMC105519/ https://ncbi.nlm.nih.gov/pubmed/9517953 https://ncbi.nlm.nih.gov/pmc/articles/PMC105520/ https://ncbi.nlm.nih.gov/pubmed/9517954 https://ncbi.nlm.nih.gov/pmc/articles/PMC105521/ https://ncbi.nlm.nih.gov/pubmed/9517955 https://ncbi.nlm.nih.gov/pmc/articles/PMC105522/ https://ncbi.nlm.nih.gov/pubmed/9517956 https://ncbi.nlm.nih.gov/pmc/articles/PMC105523/ https://ncbi.nlm.nih.gov/pubmed/9517957 https://ncbi.nlm.nih.gov/pmc/articles/PMC105524/ https://ncbi.nlm.nih.gov/pubmed/9517958 https://ncbi.nlm.nih.gov/pmc/articles/PMC105525/ https://ncbi.nlm.nih.gov/pubmed/9517959 https://ncbi.nlm.nih.gov/pmc/articles/PMC105526/ https://ncbi.nlm.nih.gov/pubmed/9517960 https://ncbi.nlm.nih.gov/pmc/articles/PMC105527/ https://ncbi.nlm.nih.gov/pubmed/9517961 https://ncbi.nlm.nih.gov/pmc/articles/PMC105528/ https://ncbi.nlm.nih.gov/pubmed/9517962 https://ncbi.nlm.nih.gov/pmc/articles/PMC105529/ https://ncbi.nlm.nih.gov/pubmed/9517963 https://ncbi.nlm.nih.gov/pmc/articles/PMC105530/ https://ncbi.nlm.nih.gov/pubmed/9517964 https://ncbi.nlm.nih.gov/pmc/articles/PMC105531/ https://ncbi.nlm.nih.gov/pubmed/9517965 https://ncbi.nlm.nih.gov/pmc/articles/PMC105532/ https://ncbi.nlm.nih.gov/pubmed/9559773 https://ncbi.nlm.nih.gov/pmc/articles/PMC105533/ https://ncbi.nlm.nih.gov/pubmed/9559774 https://ncbi.nlm.nih.gov/pmc/articles/PMC105534/ https://ncbi.nlm.nih.gov/pubmed/9559775 https://ncbi.nlm.nih.gov/pmc/articles/PMC105535/ https://ncbi.nlm.nih.gov/pubmed/9559776 https://ncbi.nlm.nih.gov/pmc/articles/PMC105536/ https://ncbi.nlm.nih.gov/pubmed/9559777 https://ncbi.nlm.nih.gov/pmc/articles/PMC105537/ https://ncbi.nlm.nih.gov/pubmed/9559778 https://ncbi.nlm.nih.gov/pmc/articles/PMC105538/ https://ncbi.nlm.nih.gov/pubmed/9559779 https://ncbi.nlm.nih.gov/pmc/articles/PMC105539/ https://ncbi.nlm.nih.gov/pubmed/9559780 https://ncbi.nlm.nih.gov/pmc/articles/PMC105540/ https://ncbi.nlm.nih.gov/pubmed/9559781 https://ncbi.nlm.nih.gov/pmc/articles/PMC105541/ https://ncbi.nlm.nih.gov/pubmed/9559782 https://ncbi.nlm.nih.gov/pmc/articles/PMC105542/ https://ncbi.nlm.nih.gov/pubmed/9559783 https://ncbi.nlm.nih.gov/pmc/articles/PMC105543/ https://ncbi.nlm.nih.gov/pubmed/9559784 https://ncbi.nlm.nih.gov/pmc/articles/PMC105544/ https://ncbi.nlm.nih.gov/pubmed/9559785 https://ncbi.nlm.nih.gov/pmc/articles/PMC105545/ https://ncbi.nlm.nih.gov/pubmed/9559786 https://ncbi.nlm.nih.gov/pmc/articles/PMC105546/ https://ncbi.nlm.nih.gov/pubmed/9559787 https://ncbi.nlm.nih.gov/pmc/articles/PMC105547/ https://ncbi.nlm.nih.gov/pubmed/9559788 https://ncbi.nlm.nih.gov/pmc/articles/PMC105548/ https://ncbi.nlm.nih.gov/pubmed/9559789 https://ncbi.nlm.nih.gov/pmc/articles/PMC105549/ https://ncbi.nlm.nih.gov/pubmed/9559790 https://ncbi.nlm.nih.gov/pmc/articles/PMC105550/ https://ncbi.nlm.nih.gov/pubmed/9559791 https://ncbi.nlm.nih.gov/pmc/articles/PMC105551/ https://ncbi.nlm.nih.gov/pubmed/9559792 https://ncbi.nlm.nih.gov/pmc/articles/PMC105552/ https://ncbi.nlm.nih.gov/pubmed/9559793 https://ncbi.nlm.nih.gov/pmc/articles/PMC105553/ https://ncbi.nlm.nih.gov/pubmed/9559794 https://ncbi.nlm.nih.gov/pmc/articles/PMC105554/ https://ncbi.nlm.nih.gov/pubmed/9559795 https://ncbi.nlm.nih.gov/pmc/articles/PMC105555/ https://ncbi.nlm.nih.gov/pubmed/9559796 https://ncbi.nlm.nih.gov/pmc/articles/PMC105556/ https://ncbi.nlm.nih.gov/pubmed/9559797 https://ncbi.nlm.nih.gov/pmc/articles/PMC105557/ https://ncbi.nlm.nih.gov/pubmed/9559798 https://ncbi.nlm.nih.gov/pmc/articles/PMC105558/ https://ncbi.nlm.nih.gov/pubmed/9559799 https://ncbi.nlm.nih.gov/pmc/articles/PMC105559/ https://ncbi.nlm.nih.gov/pubmed/9559800 https://ncbi.nlm.nih.gov/pmc/articles/PMC105560/ https://ncbi.nlm.nih.gov/pubmed/9559801 https://ncbi.nlm.nih.gov/pmc/articles/PMC105561/ https://ncbi.nlm.nih.gov/pubmed/9559802 https://ncbi.nlm.nih.gov/pmc/articles/PMC105562/ https://ncbi.nlm.nih.gov/pubmed/9559803 https://ncbi.nlm.nih.gov/pmc/articles/PMC105563/ https://ncbi.nlm.nih.gov/pubmed/9559804 https://ncbi.nlm.nih.gov/pmc/articles/PMC105564/ https://ncbi.nlm.nih.gov/pubmed/9559805
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Anti-Pneumocystis Activities of Aromatic Diamidoxime Prodrugs

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