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Proteasome Inhibitors Block Development of Plasmodium spp.

Proteasomes degrade most of the proteins inside eukaryotic cells, including transcription factors and regulators of cell cycle progression. Here we show that nanomolar concentrations of lactacystin, a specific irreversible inhibitor of the 20S proteasome, inhibit development of the exoerythrocytic a...

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Detalhes bibliográficos
Main Authors: Gantt, Soren M., Myung, Joon Mo, Briones, Marcelo R. S., Li, Wei Dong, Corey, E. J., Omura, Satoshi, Nussenzweig, Victor, Sinnis, Photini
Formato: Artigo
Idioma:en
Publicado em: American Society for Microbiology 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC105928/
https://ncbi.nlm.nih.gov/pubmed/9756786
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