The role of insulin receptor substrate 2 in hypothalamic and β cell function

Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 in β cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all neurons (NesCreIrs2KO), and in proopiomelanocortin neurons (POMCCreIrs2KO) to determine the role of Irs2 in the CNS...

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Detalhes bibliográficos
Main Authors: Choudhury, Agharul I., Heffron, Helen, Smith, Mark A., Al-Qassab, Hind, Xu, Allison W., Selman, Colin, Simmgen, Marcus, Clements, Melanie, Claret, Marc, MacColl, Gavin, Bedford, David C., Hisadome, Kazunari, Diakonov, Ivan, Moosajee, Vazira, Bell, Jimmy D., Speakman, John R., Batterham, Rachel L., Barsh, Gregory S., Ashford, Michael L.J., Withers, Dominic J.
Formato: Artigo
Idioma:English
Publicado em: American Society for Clinical Investigation 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1069106/
https://ncbi.nlm.nih.gov/pubmed/15841180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200524445
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https://ncbi.nlm.nih.gov/pmc/articles/PMC1069106/
https://ncbi.nlm.nih.gov/pubmed/15841180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200524445

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