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Investigation of the potentiation of the analgesic effects of fentanyl by ketamine in humans: a double-blinded, randomised, placebo controlled, crossover study of experimental pain[ISRCTN83088383]

BACKGROUND: Despite preclinical evidence suggesting a synergistic interaction between ketamine and opioids promoting analgesia, several clinical trials have not identified dosing regimens capable of eliciting a benefit in the co-administration of ketamine with opioids. METHODS: Ten healthy volunteer...

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Detalhes bibliográficos
Main Authors: Tucker, Adam P, Kim, Yong Ik, Nadeson, Raymond, Goodchild, Colin S
Formato: Artigo
Idioma:English
Publicado em: BioMed Central 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1084341/
https://ncbi.nlm.nih.gov/pubmed/15804361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2253-5-2
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