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The cHS4 Insulator Increases the Probability of Retroviral Expression at Random Chromosomal Integration Sites
Retroviruses are highly susceptible to transcriptional silencing and position effects imparted by chromosomal sequences at their integration site. These phenomena hamper the use of recombinant retroviruses as stable gene delivery vectors. As insulators are able to block promoter-enhancer interaction...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | en |
| Publicado em: |
American Society for Microbiology
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC111989/ https://ncbi.nlm.nih.gov/pubmed/10775605 |
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