Purified recombinant human prosaposin forms oligomers that bind procathepsin D and affect its autoactivation

Before delivery to endosomes, portions of proCD (procathepsin D) and proSAP (prosaposin) are assembled into complexes. We demonstrate that such complexes are also present in secretions of cultured cells. To study the formation and properties of the complexes, we purified proCD and proSAP from cultur...

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Detalhes bibliográficos
Main Authors: Gopalakrishnan, Madanan Madathiparambil, Grosch, Hans-Wilhelm, Locatelli-Hoops, Silvia, Werth, Norbert, Smolenová, Eva, Nettersheim, Michael, Sandhoff, Konrad, Hasilik, Andrej
Formato: Artigo
Idioma:English
Publicado em: Portland Press Ltd. 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133744/
https://ncbi.nlm.nih.gov/pubmed/15255780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040175
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Internet

https://ncbi.nlm.nih.gov/pmc/articles/PMC1133744/
https://ncbi.nlm.nih.gov/pubmed/15255780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040175

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