Cryo-EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization.

Interaction of the adenovirus penton base protein with alpha v integrins promotes virus entry into host cells. The location of the integrin binding sequence Arg-Gly-Asp (RGD) on human type 2 adenovirus (Ad2) was visualized by cryo-electron microscopy (cryo-EM) and image reconstruction using a mAb (D...

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Detalhes bibliográficos
Main Authors: Stewart, P L, Chiu, C Y, Huang, S, Muir, T, Zhao, Y, Chait, B, Mathias, P, Nemerow, G R
Formato: Artigo
Idioma:English
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1169718/
https://ncbi.nlm.nih.gov/pubmed/9135136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.6.1189
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https://ncbi.nlm.nih.gov/pmc/articles/PMC1169718/
https://ncbi.nlm.nih.gov/pubmed/9135136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.6.1189

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