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Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.
Mitochondrial cytochrome c, which functions as an electron carrier in the respiratory chain, translocates to the cytosol in cells undergoing apoptosis, where it participates in the activation of DEVD-specific caspases. The apoptosis inhibitors Bcl-2 or Bcl-xL prevent the efflux of cytochrome c from...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | English |
| Udgivet: |
1998
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1170356/ https://ncbi.nlm.nih.gov/pubmed/9427739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.1.37 |
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