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A single amino acid substitution in a WW-like domain of diverse members of the PDGF receptor subfamily of tyrosine kinases causes constitutive receptor activation.
Platelet-derived growth factor beta receptor (PDGFbetaR) is a transmembrane receptor tyrosine kinase involved in a variety of cellular functions. We have generated a constitutively activated murine PDGFbetaR containing a valine to alanine substitution at residue 536, located in the cytoplasmic juxta...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171039/ https://ncbi.nlm.nih.gov/pubmed/9843497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.23.6912 |
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