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Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase.

The Saccharomyces cerevisiae Rad53 protein kinase is required for the execution of checkpoint arrest at multiple stages of the cell cycle. We found that Rad53 autophosphorylation activity depends on in trans phosphorylation mediated by Mec1 and does not require physical association with other protei...

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Detalhes bibliográficos
Main Authors: Pellicioli, A, Lucca, C, Liberi, G, Marini, F, Lopes, M, Plevani, P, Romano, A, Di Fiore, P P, Foiani, M
Formato: Artigo
Idioma:English
Publicado em: 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171719/
https://ncbi.nlm.nih.gov/pubmed/10562568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.22.6561
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