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Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection

The role of cytotoxic T-lymphocyte (CTL) escape in rapidly progressive infant human immunodeficiency virus type 1 (HIV-1) infection is undefined. The data presented here demonstrate that infant HIV-1-specific CTL can select for viral escape variants very early in life. These variants, furthermore, m...

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Detalhes bibliográficos
Main Authors: Pillay, Thillagavathie, Zhang, Hua-Tang, Drijfhout, Jan W., Robinson, Nicola, Brown, Helen, Khan, Munira, Moodley, Jagadesa, Adhikari, Miriam, Pfafferott, Katja, Feeney, Margaret E., St. John, Anne, Holmes, Edward C., Coovadia, Hoosen M., Klenerman, Paul, Goulder, Philip J. R., Phillips, Rodney E.
Formato: Artigo
Idioma:English
Publicado em: American Society for Microbiology 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1212591/
https://ncbi.nlm.nih.gov/pubmed/16140787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.18.12100-12105.2005
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