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Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3β but not of cyclin-dependent kinase 5 and c-Jun NH(2)-terminal kinase and concomitantly abolishes hyperphosphorylation of τ: Implications for Alzheimer's disease

We have shown previously that glycogen synthase kinase-3β (GSK-3β), cyclin-dependent kinase 5, and c-Jun NH(2)-terminal kinase become overactivated and hyperphosphorylate τ in heat-shocked female rats. This hyperphosphorylation of τ is estrogen-independent, prevented by androgens, and similar to Alz...

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Detalhes bibliográficos
Main Authors: Papasozomenos, Sozos Ch., Shanavas, Alikunju
Formato: Artigo
Idioma:en
Publicado em: The National Academy of Sciences 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC122157/
https://ncbi.nlm.nih.gov/pubmed/11805297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.032646799
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