A transcriptional signaling pathway in the IFN system mediated by 2′-5′-oligoadenylate activation of RNase L

Virus replication in higher vertebrates is restrained by IFNs that cause cells to transcribe genes encoding antiviral proteins, such as 2′-5′ oligoadenylate synthetases. 2′-5′ oligoadenylate synthetase is stimulated by dsRNA to produce 5′-phosphorylated, 2′-5′-linked oligoadenylates (2-5A), whose fu...

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Detalhes bibliográficos
Main Authors: Malathi, Krishnamurthy, Paranjape, Jayashree M., Bulanova, Elena, Shim, Minsub, Guenther-Johnson, Jeanna M., Faber, Pieter W., Eling, Thomas E., Williams, Bryan R. G., Silverman, Robert H.
Formato: Artigo
Idioma:English
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1239948/
https://ncbi.nlm.nih.gov/pubmed/16203993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507551102
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https://ncbi.nlm.nih.gov/pmc/articles/PMC1239948/
https://ncbi.nlm.nih.gov/pubmed/16203993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507551102

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