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In vivo properties of an anti-GnRH Spiegelmer: An example of an oligonucleotide-based therapeutic substance class
Spiegelmers are high-affinity l-enantiomeric oligonucleotide ligands that display high resistance to enzymatic degradation compared with d-oligonucleotides. The target binding properties of Spiegelmers can be designed by an in vitro-selection process starting from a random pool of oligonucleotides....
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | en |
| Publicado em: |
National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC124395/ https://ncbi.nlm.nih.gov/pubmed/12070349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132067399 |
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