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Amyotrophic lateral sclerosis: A proposed mechanism
Missense mutations in Cu,Zn-superoxide dismutase (SOD1) account for ≈20% of familial amyotrophic lateral sclerosis (FALS) through some, as yet undefined, toxic gain of function that leads to gradual death of motor neurons. Mitochondrial swelling and vacuolization are early signs of incipient motor n...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | en |
| Publicado em: |
National Academy of Sciences
2002
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC124414/ https://ncbi.nlm.nih.gov/pubmed/12060716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132260399 |
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