Soluble Axl Is Generated by ADAM10-Dependent Cleavage and Associates with Gas6 in Mouse Serum

Axl receptor tyrosine kinase exists as a transmembrane protein and as a soluble molecule. We show that constitutive and phorbol 12-myristate 13-acetate-induced generation of soluble Axl (sAxl) involves the activity of disintegrin-like metalloproteinase 10 (ADAM10). Spontaneous and inducible Axl clea...

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Detalhes bibliográficos
Main Authors: Budagian, Vadim, Bulanova, Elena, Orinska, Zane, Duitman, Erwin, Brandt, Katja, Ludwig, Andreas, Hartmann, Dieter, Lemke, Greg, Saftig, Paul, Bulfone-Paus, Silvia
Formato: Artigo
Idioma:English
Publicado em: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1265819/
https://ncbi.nlm.nih.gov/pubmed/16227584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.21.9324-9339.2005
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https://ncbi.nlm.nih.gov/pmc/articles/PMC1265819/
https://ncbi.nlm.nih.gov/pubmed/16227584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.21.9324-9339.2005

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