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The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation

The Na,K-ATPase contains a binding site for cardiac glycosides, such as ouabain, digoxin, and digitoxin, which is highly conserved among species ranging from Drosophila to humans. Although advantage has been taken of this site to treat congestive heart failure with drugs such as digoxin, it is unkno...

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Detalhes bibliográficos
Main Authors: Dostanic-Larson, Iva, Van Huysse, James W., Lorenz, John N., Lingrel, Jerry B
Formato: Artigo
Idioma:English
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276084/
https://ncbi.nlm.nih.gov/pubmed/16243970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507358102
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