Induction of apoptosis and activation of NF-κB by CD95 require different signalling thresholds

Mutations in the death domain of the death receptor CD95 (APO-1/Fas) cause lymphoproliferation and autoimmune disease in both lpr(cg) mice and in patients with autoimmune lymphoproliferative syndrome (ALPS) type Ia. By testing lymphocytes from ALPS type Ia patients, comparing heterozygous with homoz...

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Detalhes bibliográficos
Main Authors: Legembre, Patrick, Barnhart, Bryan C, Zheng, Lixin, Vijayan, Shrijay, Straus, Stephen E, Puck, Jennifer, Dale, Janet K, Lenardo, Michael, Peter, Marcus E
Formato: Artigo
Idioma:English
Publicado em: 2004
Assuntos:
Scientific Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1299175/
https://ncbi.nlm.nih.gov/pubmed/15514680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400280
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https://ncbi.nlm.nih.gov/pmc/articles/PMC1299175/
https://ncbi.nlm.nih.gov/pubmed/15514680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400280

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