Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions

The BRCA2 tumor suppressor plays an important role in the repair of DNA damage by homologous recombination, also termed homology-directed repair (HDR). Human BRCA2 is 3,418 aa and is composed of several domains. The central part of the protein contains multiple copies of a motif that binds the Rad51...

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Main Authors: Saeki, Hiroshi, Siaud, Nicolas, Christ, Nicole, Wiegant, Wouter W., van Buul, Paul P. W., Han, Mingguang, Zdzienicka, Małgorzata Z., Stark, Jeremy M., Jasin, Maria
Formato: Artigo
Idioma:English
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482653/
https://ncbi.nlm.nih.gov/pubmed/16731627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600298103
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https://ncbi.nlm.nih.gov/pmc/articles/PMC1482653/
https://ncbi.nlm.nih.gov/pubmed/16731627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600298103

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