Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants

BACKGROUND: Experimental animal data show that protection against severe acute respiratory syndrome coronavirus (SARS-CoV) infection with human monoclonal antibodies (mAbs) is feasible. For an effective immune prophylaxis in humans, broad coverage of different strains of SARS-CoV and control of pote...

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Main Authors: ter Meulen, Jan, van den Brink, Edward N, Poon, Leo L. M, Marissen, Wilfred E, Leung, Cynthia S. W, Cox, Freek, Cheung, Chung Y, Bakker, Arjen Q, Bogaards, Johannes A, van Deventer, Els, Preiser, Wolfgang, Doerr, Hans Wilhelm, Chow, Vincent T, de Kruif, John, Peiris, Joseph S. M, Goudsmit, Jaap
Formato: Artigo
Idioma:English
Publicado em: Public Library of Science 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1483912/
https://ncbi.nlm.nih.gov/pubmed/16796401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0030237
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https://ncbi.nlm.nih.gov/pmc/articles/PMC1483912/
https://ncbi.nlm.nih.gov/pubmed/16796401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0030237

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